Premotor and non-motor features of Parkinson’s disease
Identifieur interne : 000964 ( Main/Exploration ); précédent : 000963; suivant : 000965Premotor and non-motor features of Parkinson’s disease
Auteurs : Jennifer G. Goldman [États-Unis] ; Ron Postuma [Canada]Source :
- Current opinion in neurology [ 1350-7540 ] ; 2014.
English descriptors
- KwdEn :
- MESH :
- complications : Parkinson Disease.
- etiology : Autonomic Nervous System Diseases, Cognition Disorders, Olfaction Disorders, Sleep Wake Disorders.
- Humans, Motor Activity.
Abstract
This review highlights recent advances in premotor and non-motor features in Parkinson’s disease, focusing on these issues in the context of prodromal and early stage Parkinson’s disease.
While Parkinson’s disease patients experience a wide range of non-motor symptoms throughout the disease course, studies demonstrate that non-motor features are not solely a late manifestation. Indeed, disturbances of smell, sleep, mood, and gastrointestinal function may herald Parkinson’s disease or related synucleinopathies and precede these neurodegenerative conditions by 5 or more years. In addition, other non-motor symptoms such as cognitive impairment are now recognized in incident or de novo Parkinson’s disease cohorts. Many of these non-motor features reflect disturbances in non-dopaminergic systems and early involvement of peripheral and central nervous systems including olfactory, enteric, and brainstem neurons as in Braak’s proposed pathological staging of Parkinson’s disease. Current research focuses on identifying potential biomarkers that may detect persons at risk for Parkinson’s disease and permit early intervention with neuroprotective or disease-modifying therapeutics.
Recent studies provide new insights on the frequency, pathophysiology, and importance of non-motor features in Parkinson’s disease as well as the recognition that these non-motor symptoms occur in premotor, early, and later phases of Parkinson’s disease.
Url:
DOI: 10.1097/WCO.0000000000000112
PubMed: 24978368
PubMed Central: 4181670
Affiliations:
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Le document en format XML
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Goldman</name><affiliation wicri:level="1"><nlm:aff id="A1">Rush University Medical Center, Department of Neurological Sciences, Section of Parkinson Disease and Movement Disorders, Chicago IL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Rush University Medical Center, Department of Neurological Sciences, Section of Parkinson Disease and Movement Disorders, Chicago IL</wicri:regionArea><wicri:noRegion>Chicago IL</wicri:noRegion></affiliation></author><author><name sortKey="Postuma, Ron" sort="Postuma, Ron" uniqKey="Postuma R" first="Ron" last="Postuma">Ron Postuma</name><affiliation wicri:level="4"><nlm:aff id="A2">McGill University, Montreal General Hospital, Department of Neurology, Montreal, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>McGill University, Montreal General Hospital, Department of Neurology, Montreal</wicri:regionArea><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region><settlement type="city">Montréal</settlement></placeName><orgName type="university">Université McGill</orgName></affiliation></author></analytic><series><title level="j">Current opinion in neurology</title><idno type="ISSN">1350-7540</idno><idno type="eISSN">1473-6551</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Autonomic Nervous System Diseases (etiology)</term><term>Cognition Disorders (etiology)</term><term>Humans</term><term>Motor Activity</term><term>Olfaction Disorders (etiology)</term><term>Parkinson Disease (complications)</term><term>Sleep Wake Disorders (etiology)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Autonomic Nervous System Diseases</term><term>Cognition Disorders</term><term>Olfaction Disorders</term><term>Sleep Wake Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Motor Activity</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Purpose of review</title><p id="P1">This review highlights recent advances in premotor and non-motor features in Parkinson’s disease, focusing on these issues in the context of prodromal and early stage Parkinson’s disease.</p></sec><sec id="S2"><title>Recent findings</title><p id="P2">While Parkinson’s disease patients experience a wide range of non-motor symptoms throughout the disease course, studies demonstrate that non-motor features are not solely a late manifestation. Indeed, disturbances of smell, sleep, mood, and gastrointestinal function may herald Parkinson’s disease or related synucleinopathies and precede these neurodegenerative conditions by 5 or more years. In addition, other non-motor symptoms such as cognitive impairment are now recognized in incident or de novo Parkinson’s disease cohorts. Many of these non-motor features reflect disturbances in non-dopaminergic systems and early involvement of peripheral and central nervous systems including olfactory, enteric, and brainstem neurons as in Braak’s proposed pathological staging of Parkinson’s disease. Current research focuses on identifying potential biomarkers that may detect persons at risk for Parkinson’s disease and permit early intervention with neuroprotective or disease-modifying therapeutics.</p></sec><sec id="S3"><title>Summary</title><p id="P3">Recent studies provide new insights on the frequency, pathophysiology, and importance of non-motor features in Parkinson’s disease as well as the recognition that these non-motor symptoms occur in premotor, early, and later phases of Parkinson’s disease.</p></sec></div></front></TEI><affiliations><list><country><li>Canada</li><li>États-Unis</li></country><region><li>Québec</li></region><settlement><li>Montréal</li></settlement><orgName><li>Université McGill</li></orgName></list><tree><country name="États-Unis"><noRegion><name sortKey="Goldman, Jennifer G" sort="Goldman, Jennifer G" uniqKey="Goldman J" first="Jennifer G." last="Goldman">Jennifer G. Goldman</name></noRegion></country><country name="Canada"><region name="Québec"><name sortKey="Postuma, Ron" sort="Postuma, Ron" uniqKey="Postuma R" first="Ron" last="Postuma">Ron Postuma</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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